A 205804,4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxaMide
4-(4-methylphenyl)sulfanylthieno[2,3-c]pyridine-2-carboxamide
CAS: 251992-66-2
Molecular Formula: C15H12N2OS2
A 205804,4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxaMide - Names and Identifiers
A 205804,4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxaMide - Physico-chemical Properties
| Molecular Formula | C15H12N2OS2 |
| Molar Mass | 300.4 |
| Density | 1.40±0.1 g/cm3(Predicted) |
| Melting Point | 198-199℃ |
| Boling Point | 581.3±45.0 °C(Predicted) |
| Appearance | powder to crystal |
| Color | White to Orange to Green |
| pKa | 15.12±0.30(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| In vitro study | A-205804 exhibits Cellular Toxicities for HUVEC with an IC 50 of 152 μM. A-205804 is an effective inhibitor of cell-cell adhesion in an in vitro flow experiment, demonstrating relevance in a model physiological system. |
A 205804,4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxaMide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.329 ml | 16.645 ml | 33.289 ml |
| 5 mM | 0.666 ml | 3.329 ml | 6.658 ml |
| 10 mM | 0.333 ml | 1.664 ml | 3.329 ml |
| 5 mM | 0.067 ml | 0.333 ml | 0.666 ml |
Last Update：2024-01-02 23:10:35
A 205804,4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxaMide - Reference Information
| biological activity | A-205804 is an orally effective, potent and selective lead inhibitor that inhibits the expression of E-selectin and ICAM-1, the IC50 for E-selectin and ICAM-1 effects were 20 nM and 25 nM, respectively. A- 205804 can be used in the study of chronic inflammatory diseases. |
| Target | IC50: 20 nM (E-selectin), 25 nM (ICAM-1) |
| Animal Model: | C57BL/6 mice Rat |
| Dosage: | 10 mg/kg 5 mg/kg (Pharmacokinetic Analysis) |
| Administration: | Oral administration, 3 times per week, for 2 weeks Oral administration |
| Result: | Efficiently decreased the expression of E-selectin on the endothelial vascular niche cells t 1/2 = 1 hour |
Last Update：2024-04-09 21:32:11
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Spot supply
Product Name: 4-(4-methylphenyl)sulfanylthieno[2,3-c]pyridine-2-carboxamide Visit Supplier Webpage Request for quotationCAS: 251992-66-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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